Using the potential of
organoid technology
Human midbrain organoids
Midbrain organoids can be generated from somatic samples taken from any healthy individual or PD patient.
Key Publications:
Patent:
MIDBRAIN ORGANOIDS
Organoids contain high amount of dopaminergic neurons but also other type of neurons (GABAergic, glutamatergic) and astrocytes
FURTHER DEVELOPMENT
hey can be enriched with endothelial cells and microglia
PHENOTYPING
Midbrain organoids from PD patients show dopaminergic neuron impairment
DISCOVERY
State-of-the-art tool for drug discovery
Midbrain organoids show a high abundance of dopaminergic neurons (TH) which produce the neurotransmitter dopamine
Organoids show expression of markers confirming the midbrain identity such as LMX1 and FOXA2
Screening pipeline
Image analysis and artifical intelligence
We use a set of computational AI tools to perform deep phenotyping of our models to better detect cellular defects and their rescue following compound treatments. Fore more details see our publication.